Skincare ingredients for rosacea
Our research data links 23 ingredients to rosacea. Strongest evidence comes first, each with the studies behind it.
A research list, not medical advice. If a skin condition worries you, see a dermatologist.
Which ingredients have the most evidence for rosacea?
In our data, the strongest evidence for rosacea is behind Azelaic acid, Dexpanthenol, and White Petrolatum.
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| Ingredient | Evidence | Studied at | Rating |
|---|---|---|---|
| Azelaic acid | 🧪 Clinical evidence | Study dose: not found yet | Moderate concern |
| Dexpanthenol | 🧪 Clinical evidence | 5% | Low concern |
| White Petrolatum | 📄 Literature evidence | Study dose: not found yet | Low concern |
| Niacinamide | 🧪 Clinical evidence | 2-5% | Low concern |
| Ectoine | 🧪 Clinical evidence | 7% | Low concern |
- Azelaic acidModerate concern
Study dose: not found yet
For papulopustular rosacea at 15%. The effect on persistent erythema without lesions alone is not assessed on the label.
- Reference: Balina and Graupe, 1991
- Reference: DailyMed drug label, 2020
Pregnancy: use with care · Listed in 89 products
- DexpanthenolLow concern
Studied at 5%
- Reference: Proksch and Nissen, 2002
Pregnancy: not advised against on skin · Listed in 127 products
- White PetrolatumLow concern
Petrolatum
Study dose: not found yet
- Reference: Ghadially et al., 1992
Pregnancy: – · Listed in 345 products
- NiacinamideLow concern
Studied at 2-5%
- Korea approved amount: 2-5%
A limit is the most a product may hold, not the amount that works.
- Reference: Bissett et al., 2004
- Reference: Draelos et al., 2006
- Reference: Kimball et al., 2010
- Reference: Korea Ministry of Government Legislation, 2023
Pregnancy: – · Listed in 12,904 products
- EctoineLow concern
Ectoin
Studied at 7%
- Reference: Marini et al., 2014
- Reference: Bitop AG, 2010
Pregnancy: – · Listed in 847 products
- Ceramide APLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: CIR, 2015
Pregnancy: – · Listed in 1,102 products
- Ceramide ASLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: CIR, 2015
Pregnancy: – · Listed in 723 products
- Ceramide EOPLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: CIR, 2015
Pregnancy: – · Listed in 1,078 products
- Ceramide NPLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: CIR, 2015
Pregnancy: – · Listed in 7,445 products
- Ceramide NSLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: CIR, 2015
Pregnancy: – · Listed in 819 products
- GlycerolLow concern
Glycerin
Studied only mixed with other actives
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Danby et al., 2022
Pregnancy: not advised against on skin · Listed in 30,056 products
- alpha-BisabololLow concern
Bisabolol
Study dose: not found yet
- Korea approved amount: 0.5%
A limit is the most a product may hold, not the amount that works.
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Korea Ministry of Government Legislation, 2023
Pregnancy: – · Listed in 1,378 products
- Glycyrrhetinic acidLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Cameli et al., 2020
Listed in 88 products
- Hyaluronan 2000 kDaLow concern
Studied at 0.1%
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Pavicic et al., 2011
Not in our product list yet
- MadecassosideLow concern
Studied only mixed with other actives
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Haftek et al., 2008
Pregnancy: – · Listed in 3,532 products
- AllantoinLow concern
Study dose: not found yet
- Reference: Xu et al., 2025
Pregnancy: – · Listed in 9,420 products
- PhytosphingosineLow concern
Study dose: not found yet
Indirect evidence for a barrier-support purpose. The clinical effective % of this single molecule for treating chronic inflammation in rosacea is N/A.
- Reference: Pavicic et al., 2007
- Reference: CIR, 2015
Pregnancy: – · Listed in 1,641 products
– = no pregnancy research data yet
Which ingredients for rosacea need a doctor?
6 ingredients here are prescription-only or for in-clinic use in the US. We list them so you can look them up; they never go into a PERBETE routine.
Study dose: not found yet
The 9.0 is attributed to the papulopustular effect of the approved ivermectin 1% mixed cream. The stand-alone clinical efficacy and concentration of this homologue are N/A.
- Reference: DailyMed drug label, 2024
Not in our product list yet
Study dose: not found yet
The 9.0 is attributed to the papulopustular effect of the approved ivermectin 1% mixed cream. The stand-alone clinical efficacy and concentration of this homologue are N/A.
- Reference: DailyMed drug label, 2024
Not in our product list yet
Study dose: not found yet
Temporary vasoconstriction of persistent erythema. Different from treating papulopustular, barrier or ocular rosacea; follow the product label and doctor's prescription.
- Reference: DailyMed drug label, 2024
Not in our product list yet
Study dose: not found yet
Temporary vasoconstriction of persistent erythema. Different from treating papulopustular, barrier or ocular rosacea; follow the product label and doctor's prescription.
- Reference: DailyMed drug label, 2024
Not in our product list yet
Study dose: not found yet
- Reference: DailyMed, 2025
Not in our product list yet
Study dose: not found yet
Temporary vasoconstriction of persistent erythema. Different from treating papulopustular, barrier or ocular rosacea; follow the product label and doctor's prescription.
- Reference: DailyMed drug label, 2025
Not in our product list yet
Which ingredients for rosacea are advised against in pregnancy?
None of the 23 ingredients here carries an 'advised to avoid' verdict for pregnancy in our data.
Use with care (the reason is on each ingredient page): Azelaic acid.
Pregnant or breastfeeding? Check new products with your doctor or midwife.
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